It is possible to run without swap space, but this does not obviate the desirability of minimizing writes to the SSD which occur even when a file is read (the access time stamp is updated).
There is also another school of thought. Since prices for electronics continually drop (or for the same cost the amount of storage drastically increases), you might consider ignoring optimizing altogether. This will save you time and effort now. If it becomes an issue later on, then you could buy an even bigger SSD for similar or lower prices in the future.
I think there are many people that use SSDs with no minimization of writes exactly as if these were spinning hard drives.
For myself I choose to minimize writes to SSD.